Location of Repository

Neural correlates of visuospatial working memory in the ‘at-risk mental state’

By Matthew R. Broome, Paolo Fusar-Poli, P. (Pall) Matthiasson, J. B. (James B.) Woolley, Lucia Valmaggia, Louise C. Johns, Paul Tabraham, Elvira Bramon, S. C. R. (Steven C. R.) Williams, M. J. (Mick J.) Brammer, X. Chitnis, F. Zelaya and Philip McGuire

Abstract

Background. Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to\ud the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic\ud resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just\ud developed schizophrenia.\ud Method. fMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 agematched\ud healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while\ud subjects performed an object–location paired-associate memory task, with experimental manipulation of mnemonic\ud load.\ud Results. In all groups, increasing mnemonic load was associated with activation in the medial frontal and medial\ud posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the\ud medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater\ud activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most\ud demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the\ud conditions. However, there was a significant group difference in the response of the right precuneus across repeated\ud trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS.\ud Conclusions. Abnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task\ud may be a neural correlate of increased vulnerability to psychosis

Topics: RC
Publisher: Cambridge University Press
Year: 2010
OAI identifier: oai:wrap.warwick.ac.uk:4147

Suggested articles

Preview

Citations

  1. (1988). A Co-planar Stereotactic Atlas of the Human Brain.
  2. (1991). A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. doi
  3. (2002). A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. doi
  4. (2004). Action sets and decisions in the medial frontal cortex. doi
  5. (1996). Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI. doi
  6. (2000). Activity in human frontal cortex associated with spatial working memory and saccadic behavior. doi
  7. (2003). Adaptive analysis of fMRI data. doi
  8. (2007). Analysis of a large fMRI cohort: statistical and methodological issues for group analysis. doi
  9. (2005). Belger A
  10. (2005). Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. doi
  11. (2001). Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. doi
  12. (2006). Cognitive and neurobiological risk indicators in early and late prodromal stages. doi
  13. (2001). Coloured noise and computational inference in neurophysiological (fMRI) series analysis: resampling methods in time and wavelet domains. doi
  14. (2002). Cortical and subcortical gray matter abnormalities in schizophrenia determined through structural magnetic resonance imaging with optimized volumetric voxel-based morphometry. doi
  15. (1998). Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. doi
  16. (2007). Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophrenia Bulletin 33, 673–681. Neural correlates of visuospatial working memory doi
  17. (2004). Defining the cognitive impairment in schizophrenia. doi
  18. (2007). Delusion formation and reasoning biases in those at clinical high risk for psychosis. doi
  19. (2005). Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the AESOP study. doi
  20. (2005). Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis.
  21. (2005). Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia.
  22. (2009). Economic impact of early intervention in people at high risk of psychosis. doi
  23. (1999). Episodic retrieval activates the precuneus irrespective of the imagery content of word pair associates. A PET study. doi
  24. (1999). Evans A doi
  25. (2003). fMRI BOLD response to increasing task difficulty during successful paired associates learning. doi
  26. (2005). Functional heterogeneity of the supplementary motor area.
  27. (2006). Generalized and specific neurocognitive deficits in prodromal schizophrenia. doi
  28. (1997). Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach. doi
  29. (1999). Global, voxel and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. doi
  30. (2007). Hippocampal abnormalities and memory deficits: new evidence of a strong pathophysiological link in schizophrenia. doi
  31. (1995). Individual differences in spatial working memory in relation to schizotypy. doi
  32. (1999). Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. doi
  33. (1999). Load-dependent roles of frontal brain regions in the maintenance of working memory. doi
  34. (2001). Longitudinal study of brain morphology in first episode schizophrenia. doi
  35. McGuire PK (1999b). Methods for diagnosis and treatment of stimuluscorrelated motion in generic brain activation studies using fMRI. doi
  36. McGuire PK (2005a). Outreach and support in South London (OASIS): implementation of a clinical service for prodromal psychosis and the at risk mental state. doi
  37. (2005). Memory impairments identified in people at ultra-high risk for psychosis who later develop firstepisode psychosis. doi
  38. (2009). Neural correlates of executive function and working memory in the ‘at-risk mental state’. doi
  39. (2007). Neural correlates of visuospatial working memory 1997McGuire P doi
  40. (2009). Neural substrates of visual paired associates in young adults with a history of very preterm birth: alterations in fronto-parieto-occipital networks and caudate nucleus. doi
  41. (1999). Neuroanatomic overlap of working memory and spatial attention networks: a functional MRI comparison within subjects. doi
  42. (2003). Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. doi
  43. (2007). Neurocognitive indicators for a conversion to psychosis: comparison of patients in a potentially initial prodromal doi
  44. (2000). Object working memory and visuospatial processing: functional neuroanatomy analyzed by event-related fMRI. doi
  45. (2005). Parietal lobe contributions to episodic memory retrieval. doi
  46. (1990). Positive-negative symptom assessment in schizophrenia: psychometric issues and scale comparison. doi
  47. (1998). Prediction of psychosis. A step towards indicated prevention of schizophrenia.
  48. (2006). Prefrontal and parietal contributions to spatial working memory. doi
  49. (2009). Prefrontal response during executive functioning directly related to twelve months clinical outcome in people at ultra high risk of psychosis. Schizophrenia Bulletin. Published online: 7 doi
  50. (2002). Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. doi
  51. (2003). Psychosis prediction: 12-month follow up of a high-risk (‘prodromal’) group. doi
  52. (2006). Reduced size of the pre-supplementary motor cortex and impaired motor sequence learning in first-episode schizophrenia. doi
  53. (2003). Regionally localized thinning of the cerebral cortex in schizophrenia. doi
  54. (1992). Schizophrenics show spatial working memory deficits. doi
  55. (2003). Spatial working memory ability is a marker of risk-for-psychosis. doi
  56. (2006). Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction. doi
  57. (2006). Spatial working memory deficits in adolescents at clinical high risk for schizophrenia. doi
  58. (2005). Sustained attention in young people at high risk of psychosis does not predict transition to psychosis. doi
  59. (2003). The functional neuroanatomy of schizophrenic subsyndromes. doi
  60. (2006). The functional neuroanatomy of working memory: contributions of human brain lesion studies. doi
  61. (2000). The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. doi
  62. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. doi
  63. (1999). Transient neural activity in the medial superior frontal gyrus and precuneus time locked with attention shift between object features. doi
  64. (1988). Verbal and abstract designs paired associate learning after unilateral temporal lobectomy. doi
  65. (2000). Visual perception and working memory in schizotypal personality disorder.
  66. (2005). Visuospatial learning and executive function are independently impaired in first-episode psychosis. doi
  67. (2002). Visuospatial memory and learning in first-episode schizophreniform psychosis and established schizophrenia: a functional correlate of hippocampal pathology? doi
  68. (2006). Visuospatial working memory deficits in adolescent onset schizophrenia. doi
  69. (1997). Visuospatial working memory in patients with schizophrenia. doi
  70. (2005). What causes the onset of psychosis? doi
  71. (2006). Working memory as an emergent property of the mind and brain. doi
  72. (2003). Working memory deficit as a core neuropsychological dysfunction in schizophrenia. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.