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Gene Detection in DNA Sequences

By Zbyněk Roubalík

Abstract

Gene detection in DNA sequences is one of the most difficult problems, which have been currently solved in bioinformatics. This thesis deals with gene detection in DNA sequences with methods using Hidden Markov Models. It contains a brief description of the fundamental principles of molecular biology, explains how genetic information is stored in DNA sequences, as well as the theoretical basis of the Hidden Markov Models. Further is described subsequent approach in the design of specific Hidden Markov Models for solving the problem of gene detection in DNA sequences. Is designed and implemented application, which uses previously designed Hidden Markov model for gene detection. This application is tested on the real data, results of these tests are discussed in the end of the thesis, as well as the possible extension and continuation of the project

Topics: bionformatics; Skryté Markovovy modely; gene finding; gene detection; detekce genů; gen; HMM; Hidden Markov Models; DNA sekvence; hledání genů; gene; bioinformatika; DNA sequence
Publisher: Vysoké učení technické v Brně. Fakulta informačních technologií
Year: 2011
OAI identifier: oai:invenio.nusl.cz:237026
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