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Protein Domains Prediction

By Martin Valenta


The work is focused on the area of the proteins and their domains. It also briefly describes gathering methods of the protein´s structure at the various levels of the hierarchy. This is followed by examining of existing tools for protein´s domains prediction and databases consisting of domain´s information. In the next part of the work selected representatives of prediction methods are introduced.  These methods work with the information about the internal structure of the molecule or the amino acid sequence. The appropriate chapter outlines applied procedure of domains´ boundaries prediction. The prediction is derived from the primary structure of the protein, using a neural network  The implemented procedure and its possibility of further development in the related thesis are introduced at the conclusion of this work

Topics: struktura proteinů; klasifikace proteinových domén; proteinové domény; PSI-BLAST; neural network; Back-Propagation; protein structure; PPRODO; Proteiny; databáze proteinových domén; Domain parser; InterProScan; neuronová síť; genetický algoritmus.; genetic algorithm.; Pfam; DOMpred;  PPRODO; Proteins; protein domain; DoBo; classification of protein domain. database of protein domains; SCOP; PUU; DOMpro
Publisher: Vysoké učení technické v Brně. Fakulta informačních technologií
Year: 2013
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