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Localization of Methylation Sites in Transposons

By Miroslav Kmeť

Abstract

This master's thesis deals with the creation of a tool for the extraction of methylation level from transposon sequences. Transposons are DNA elements with ability to move or copy themselves and their activity is regulated by DNA methylation. Sequence methylation information is stored in the bisulfite data and their processing is done with parts of two existing tools in a combination with implemented modules. Created tool takes into consideration unique challenges brought in the methylation calling process by transposable elements and it's functionality is presented on a set of experiments with simulated and real data

Topics: metylace; DNA; methylation; next-generation sekvenování; methylation calling; extrakce metylace; 3-písmenové mapování; transposons; transpozony; bisulfitové sekvenování; next-generation sequencing; 3-letter mapping; bisulfite sequencing
Publisher: Vysoké učení technické v Brně. Fakulta informačních technologií
Year: 2015
OAI identifier: oai:invenio.nusl.cz:235006
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