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Antibacterial, kinetics and bacteriolytic properties of silver(I) pyridinedicarboxylate compounds

By M. Ignacio Azócar, Grace Gómez, Carla Velásquez, Romina Abarca, Marcelo Kogan Bocian and Maritza Páez

Abstract

Artículo de publicación ISIAntibacterial properties of silver(I)-pyridinedicarboxylate compounds (with Pyridine-2,3-dicarboxylic(Lutidinic acid), pyridine-2,4-dicarboxylic (Quinolinic acid) and pyridine-2,5-dicarboxylic (Isocinchomeronic acid)) were studied against Escherichia coli, Listeria monocytogenes (ISP-65-08), Salmonella typhi and Staphylococcus aureus (ATCC 25923) using kinetics of grown inhibition, viability assays, minimuminhibitory concentration and optical microscopy. The 3 silver compounds were tested toward UV-radiation in order to characterize their light insensitivity for potential medical devices: UV-radiation curable polymers. Photophysical measurements show remarkable differences toward UV-radiation, which were explained based on their polymeric structures with multiple nature bonds between pyridinedicarboxylic ligands and Ag(I) centers. We found a bacteriolytic effect and differences in the antibacterial efficiency depending on the structure of the complexes and the nature of Ag\X (X = oxygen and nitrogen) bonds: AgQuinol N AgLutidin N AgIsocinchom.This work was supported by FONDECYT (Grant Nos 11080133 and 1100537), CONICYT (Grant: 79090024) FONDAP 15130011 and DICYT (No 021340AG)

Topics: Antibacterial
Publisher: 'Elsevier BV'
Year: 2014
DOI identifier: 10.1016/j.msec.2014.01.033
OAI identifier: oai:repositorio.uchile.cl:2250/121885
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