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Development of pectin nanoparticles through mechanical homogenization for dissolution enhancement of itraconazole

By Kanokporn Burapapadh, Hirofumi Takeuchi and Pornsak Sriamornsak


A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared by a mechanical homogenization using pectin as emulsifier. After freeze-drying, the morphology, crystallinity state, thermal properties, drug dissolution and stability of the obtained pectin nanoparticles were characterized. The results demonstrated that the morphology of freeze-dried products was different, depending on the type of internal phase; the nanoparticles prepared from chloroform-based nanoemulsions were completely dried and provided a fragile characteristic. The pectin nanoparticles also demonstrated good properties in terms of redispersibility, thermal properties, drug crystallinity and dissolution. The ITZ-loaded pectin nanoparticles showed high percentage of drug dissolved (about 60–80% within 2 h), and maintained their good dissolution properties even after 1-year storage. The results suggested that freeze-dried pectin nanoparticles prepared from nanoemulsions could be used as an effective carrier for enhancement of ITZ dissolution

Topics: Pectin, Poorly water-soluble drug, Itraconazole, Nanoparticles, Stability, Therapeutics. Pharmacology, RM1-950
Publisher: Elsevier
Year: 2016
DOI identifier: 10.1016/j.ajps.2015.07.003
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