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By M. Barzegar, S. Davari Farid, S. Dastgiri, A. Malekian and V. Toopchizadeh


<p> <strong>Objective</strong></p><p>This study aims at determining the epidemiologic, presenting symptoms, clinical course and electrophysiologic features of childhood Guillain-Barre Syndrome (GBS) in the East Azarbaijan province over a period of five years.</p><p><strong>Materials & Methods</strong></p><p> All the patients, aged< 15 years, referred/admitted to Tabriz Children Hospital with GBS between January 2001 and December 2005 were investigated.</p><p><strong>Results</strong></p><p>One hundred and twelve subjects were enrolled during this period. The average annual incidence rate was 2.21 per 100000 population of children aged<15 years (CI 95%: 1.8-2.6); the highest proportion of 29% was observed in winter (P=0.10); mean age (SD) of subjects was 5.1 (3.3) years, while 61.6% were ≤5 years. The ale/female ratio was 1.3. Antecedent events were identified in 80 (71.4%) patients. The most common manifestation was limb weakness; at the peak of the disease course, only 8 (7.1%) patients were able to walk without assistance. Cranial nerve involvement was found in 37.5%. Fifteen percent of patients had autonomic dysfunction, and 32.2% complained of neuropathic pain. Artificial ventilation was needed in 10.7% of patients, and three patients (2.7%) died due to cardiac arrest. Electrophysiological examination showed the demyelinating type of the disease in 54.5%; axonal type in 35.7% and 9.8% as unclassified or normal pattern. Short time to reach nadir (P=0.008), cranial nerve involvement (P=0.000),) autonomic involvement (P=0.001), and axonal pattern on electro diagnosis (P=0.043) were found as risk factors for respiratory failure.  In follow-up, at the end of one year, 95% of patients could walk without aid.</p><p><strong>Conclusion</strong></p><p align="left"> The axonal type of GBS is a relatively common form of childhood GBS occurring in East Azerbaijan.</p><p align="left"><strong>Keywords:</strong> Guillian-Barre syndrome , Childhood, Epidemiology, Electrodiagnosis, Clinical features, East Azarbaijan</p

Topics: Neurology. Diseases of the nervous system, RC346-429, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245, Medicine, R, Pediatrics, RJ1-570
Publisher: Iranian Child Neurology Society
Year: 2009
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