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Stem cells in neurology - current perspectives

By Chary Ely Marquez Batista, Eric Domingos Mariano, Suely Kazue Nagahashi Marie, Manoel Jacobsen Teixeira, Matthias Morgalla, Marcos Tatagiba, Jun Li and Guilherme Lepski

Abstract

Central nervous system (CNS) restoration is an important clinical challenge and stem cell transplantation has been considered a promising therapeutic option for many neurological diseases. Objective : The present review aims to briefly describe stem cell biology, as well as to outline the clinical application of stem cells in the treatment of diseases of the CNS. Method : Literature review of animal and human clinical experimental trials, using the following key words: “stem cell”, “neurogenesis”, “Parkinson”, “Huntington”, “amyotrophic lateral sclerosis”, “traumatic brain injury”, “spinal cord injury”, “ischemic stroke”, and “demyelinating diseases”. Conclusion : Major recent advances in stem cell research have brought us several steps closer to their effective clinical application, which aims to develop efficient ways of regenerating the damaged CNS

Topics: células-tronco, neurogênese, doenças neurológicas, terapia com células-tronco, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Academia Brasileira de Neurologia (ABNEURO)
Year: 2014
DOI identifier: 10.1590/0004-282X20140045
OAI identifier: oai:doaj.org/article:e34e439a692d4b3d8db33686f4b6b85c
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