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Expression data of HeLa cells treated with CENP-E siRNA or Eg5 siRNA in the presence of BubR1 siRNA

By Yusuke Nakayama and Akihiro Ohashi


The molecular mechanism responsible for cell fate after mitotic slippage is unclear. We investigated the postmitotic effects of different mitotic aberrations (Ohashi et al. [1]), misaligned chromosomes produced by CENP-E siRNA (siCENP-E), and monopolar spindles resulting from Eg5 siRNA (siEg5) (Miki et al. [2]). To determine which signaling pathways contribute to the postmitotic effect of siCENP-E in the presence of siBubR1 (siCENP-E + siBubR1) compared with siEg5 + siBubR1, we performed comprehensive gene expression analysis using microarray comparisons [1]. The microarray data have been deposited in NCBI's Gene Expression Omnibus (GEO) and are accessible through GEO Series accession number GSE67905

Topics: CENP-E, Eg5, BubR1, HeLa, GeneChip microarray analysis, Genetics, QH426-470
Publisher: Elsevier
Year: 2015
DOI identifier: 10.1016/j.gdata.2015.08.002
OAI identifier: oai:doaj.org/article:e3b3abd87a374c2cbcd3868e2b286c24
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