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Pneumatosis intestinalis due to gastrointestinal amyloidosis: A case report & review of literature

By Filza Khalid, Hadiel Kaiyasah, Wafa Binfadil, Maiyasa Majid, Wessam Hazim and Yousif ElTayeb


Introduction: Pneumatosis intestinalis (PI) is not a disease but a radiological finding with a poorly understood pathogenesis. It can be divided into primary/idiopathic (15%) or secondary (85%) Kim et al. 2007, based on the factors thought to play a role in its development. Amongst the rare causes of secondary PI is gastrointestinal (GI) amyloidosis. Presentation of the case: We report a case of a 46-year-old gentleman who presented with a one month history of acute on chronic abdominal pain, associated with one episode of melena. Upon further investigation, he was found to have pneumoperitoneum. He was taken to the operating theatre, where he was noted to have features of pneumatosis intestinalis of the small bowel with no evidence of bowel perforation. Postoperatively, he underwent an upper GI endoscopy with biopsies that revealed GI amyloidosis. Discussion: One of the rare causes that can lead to secondary PI is GI amyloidosis as proven in our case. Patients with symptomatic gastrointestinal amyloidosis usually present with one of four syndromes: gastrointestinal bleeding, malabsorption, protein-losing gastroenteropathy, and, less often, gastrointestinal dysmotility. Conclusion: GI amyloidosis is a rare cause of secondary pneumatosis intestinalis. The presentation of the disease varies from patient to patient, therefore, the management should be tailored accordingly

Topics: Pneumatosis intestinalis, Gastrointestinal amyloidosis, Pneumoperitoneum, Melena, Laparotomy, Endoscopy, Surgery, RD1-811
Publisher: Elsevier
Year: 2016
DOI identifier: 10.1016/j.ijscr.2016.03.044
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