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Central Nervous System Involvement of Epstein Barr Virus Associated Lymphoproliferative Disorder in a Child with Acute Lymphoblastic Leukemia: Successful Treatment with Rituximab and Interferon-Alpha

By Berna Atabay, Meral Türker, Can Öztürk, Sümer Sütçüoğlu, Haldun Öniz and Esra Arun Özer


Central nervous system (CNS) involvement of Epstein-Barr virus (EBV)-associated lymphoproliferative disease is a rare and serious complication in children with leukemia. Although rituximab therapy seems to be promising in these cases, persistent hypogammaglobulinemia may appear after treatment due to complete depletion of normal B lymphocytes in the peripheral blood. Here we report isolated CNS involvement of EBV-associated lymphoproliferative disorder in a 4-year-old boy with acute leukemia. The patient was treated with rituximab and interferon alpha; however, persistent hypogammaglobulinemia developed as a complication. Given the rarity of the complication in children receiving these agents, our experience with such a case may be helpful to others

Topics: Epstein-Barr virus, Lymphoproliferative disorder, Rituximab, Children, Leukemia, Internal medicine, RC31-1245, Diseases of the blood and blood-forming organs, RC633-647.5
Publisher: Galenos Yayinevi
Year: 2013
DOI identifier: 10.4274/tjh.2011.0047
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