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Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism

By Kerry L. Chamberlain, Richard S. Marshall, Nicholas A. Jolliffe, Lorenzo Frigerio, Aldo Ceriotti, Mike Lord and L. M. (Lynne M.) Roberts


The B chain of ricin was expressed and delivered to the endoplasmic\ud reticulum of tobacco protoplasts where it disappeared\ud with time in a manner consistent with degradation. This turnover\ud did not occur in the vacuoles or upon secretion. Indeed,\ud several lines of evidence indicate that, in contrast to the turnover\ud of endoplasmic reticulum-targeted ricin A chain in the\ud cytosol, the bulk of expressed ricin B chain was degraded in the\ud secretory pathway

Topics: QR
Publisher: American Society for Biochemistry and Molecular Biology, Inc.
Year: 2008
OAI identifier:

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