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Prospects for malaria eradication in sub-Saharan Africa

By Ricardo Águas, L. J. White, Robert W. Snow and M. Gabriela M. Gomes

Abstract

Background: A characteristic of Plasmodium falciparum infections is the gradual acquisition of clinical immunity resulting\ud from repeated exposures to the parasite. While the molecular basis of protection against clinical malaria remains\ud unresolved, its effects on epidemiological patterns are well recognized. Accumulating epidemiological data constitute a\ud valuable resource that must be intensively explored and interpreted as to effectively inform control planning.\ud Methodology/Principal Finding: Here we apply a mathematical model to clinical data from eight endemic regions in sub-\ud Saharan Africa. The model provides a quantitative framework within which differences in age distribution of clinical disease\ud are assessed in terms of the parameters underlying transmission. The shorter infectious periods estimated for clinical\ud infections induce a regime of bistability of endemic and malaria-free states in regions of mesoendemic transmission. The\ud two epidemiological states are separated by a threshold that provides a convenient measure for intervention design.\ud Scenarios of eradication and resurgence are simulated.\ud Conclusions/Significance: In regions that support mesoendemic transmission, intervention success depends critically on\ud reducing prevalence below a threshold which separates endemic and malaria-free regimes

Topics: RA
Publisher: Public Library of Science
Year: 2008
OAI identifier: oai:wrap.warwick.ac.uk:4432

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  1. (2006). An epidemiologic model of the incidence of acute illness in Plasmodium falciparum malaria.
  2. (2005). Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria. doi
  3. (2001). Endemic stability–a veterinary idea applied to human public health. doi
  4. (2005). Epidemic malaria in the highlands of Papua New Guinea.
  5. (1999). Estimating mortality, morbidity and disability due to malaria among Africa’s non-pregnant population,
  6. (2006). Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum. PLoS Clin Trials. doi
  7. (2001). Hepatitis-B virus endemicity: heterogeneity, catastrophic dynamics and control.
  8. (2004). Historical review of malarial control in southern Africa with emphasis on the use of indoor residual house-spraying. Trop Med Int Health. doi
  9. (1999). Immunity to non-cerebral severe malaria is acquired after one or two infections.
  10. (1996). Incorporating Immunological Ideas in Epidemiological Models, doi
  11. (2003). Low recovery rates stabilize malaria endemicity in areas of low transmission in coastal Kenya. doi
  12. (2000). Malaria on the move: human population movement and malaria transmission. Emerg Infect Dis. doi
  13. (2003). Mass administration of antimalarial drugs. doi
  14. (1992). Modeling transmission dynamics of stagespecific Malaria vaccines. Parasitology Today. doi
  15. (1998). New insights into the epidemiology of malaria relevant for disease control. doi
  16. (2006). Pertussis: increasing disease as a consequence of reducing transmission. doi
  17. (1999). Plasmodium falciparum clinical malaria in Dielmo, a holoendemic area in Senegal: no influence of acquired immunity on initial symptomatology and severity of malaria attacks.
  18. (2004). Plasmodium falciparum malaria disease manifestations in humans and transmission to Anopheles gambiae: a field study in Western Kenya. doi
  19. (2005). Population, Resources, Environment and Development: The doi
  20. (2007). Preventing childhood malaria in Africa by protecting adults from mosquitoes with insecticide-treated nets. doi
  21. (1997). Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. doi
  22. (2006). Relationship between the entomological inoculation rate and the force of infection for Plasmodium falciparum malaria.
  23. (2004). Relationships between the outcome of Plasmodium falciparum infection and the intensity of transmission in Africa.
  24. (2007). Revisiting the basic reproduction number for malaria control. doi
  25. (1999). Spielman A
  26. (2002). The consequences of reducing transmission of Plasmodium falciparum in Africa. doi
  27. (2005). The entomological inoculation rate and Plasmodium falciparum infection in African children. doi
  28. (1980). The Garki Project. Geneva: World Health Organisation.
  29. (2005). The global distribution of clinical episodes of Plasmodium falciparum malaria. doi
  30. (2004). The immuno-epidemiology of pregnancy-associated Plasmodium falciparum malaria: a variant surface antigen-specific perspective. doi
  31. (2002). The pathogenic basis of malaria. doi
  32. (1988). The recent history of malaria control and eradication.
  33. (2004). The risk of a mosquito-borne infection in a heterogeneous environment. doi
  34. (2002). The role of antibodies to Plasmodium falciparuminfected-erythrocyte surface antigens in naturally acquired immunity to malaria. doi
  35. (2005). The Transmission dynamics of group A and B human respiratory syncytial virus (hRSV) in England and Wales and Finland: seasonality and cross-protection. Epidemiology and Infection. doi
  36. (1974). Thomas A

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