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β-Glucan exacerbates allergic airway responses to house dust mite allergen

By Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I Murray, David L Williams, Bart N Lambrecht, Frank Brombacher and Gordon D Brown

Abstract

β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation

Publisher: University of Cape Town
Year: 2016
DOI identifier: 10.1186/s12931-016-0352-5
OAI identifier: oai:open.uct.ac.za:11427/19794
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