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The Evolutionary Value of Recombination Is Constrained by Genome Modularity

By Darren P Martin, Eric van der Walt, David Posada and Edward P Rybicki

Abstract

Genetic recombination is a fundamental evolutionary mechanism promoting biological adaptation. Using engineered recombinants of the small single-stranded DNA plant virus, Maize streak virus (MSV), we experimentally demonstrate that fragments of genetic material only function optimally if they reside within genomes similar to those in which they evolved. The degree of similarity necessary for optimal functionality is correlated with the complexity of intragenomic interaction networks within which genome fragments must function. There is a striking correlation between our experimental results and the types of MSV recombinants that are detectable in nature, indicating that obligatory maintenance of intragenome interaction networks strongly constrains the evolutionary value of recombination for this virus and probably for genomes in general

Topics: Plant genomics, Viral genomics, DNA recombination, Genome evolution, Viral evolution, Evolutionary genetics, Genome complexity, Organismal evolution
Publisher: Institute of Infectious Disease & Molecular Medicine
Year: 2005
DOI identifier: 10.1371/journal.pgen.0010051
OAI identifier: oai:open.uct.ac.za:11427/14783
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