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Ocular dynamics of <i>Garcinia cola</i> (Heckel) on healthy volunteers following bolus ingestion

By S. A. Igwe and D. N. Akunyili


Garcinia cola Heckel, an angiospermae belonging to the  family Guttiferae, is known in commerce as bitter cola. It is a plant found <br />in the West African subregion, mostly in moist conditions, and often in association with Cola acuminata. The seeds are highly valued ingredients in African ethonomedicine. The seeds <br />have several social uses and applications in folk medicine. These seeds are ordinarily chewed by the local people without prescription or restriction. In an in vivo case control study, the effects of Garcinia cola on some visual functions: pupil diameter, near point of convergence (NPC), amplitude of accommodation (AA), <br />intraocular pressure (IOP), visual acuity (VA) and habitual phoria; following bolus ingestion of 20 g was undertaken using healthy visually active volunteers. Results showed that bolus ingestion of Garcinia cola constricted the pupil by 68%, reduced the NPC by 28%, increased the AA by 17.8% at peak effect and decreased <br />the intraocular pressure by 31% without affecting the distance and near VA. The lateral phoria at far and near tended towards esophoria. Possibly the miotic effect and reduction in IOP <br />could be of benefit to patients with raised IOP where conventional drugs may not be effective. Also it is possible that the effects on phoria could be exploited in oculomotor function in combination with visual training

Topics: Bolus ingestion, Garcinia cola, ocular dynamics, oculomotor, intraocular pressure., Ophthalmology, RE1-994
Publisher: AOSIS
Year: 2007
DOI identifier: 10.4102/aveh.v66i1.202
OAI identifier: oai:doaj.org/article:58fb790fc15d4d2380dbc64972b5d940
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