Skip to main content
Article thumbnail
Location of Repository

MRI diagnosis of Alexander disease

By C G Muralidharan, R P S Tomar and R Aggarwal


Alexander disease (fibrinoid leucodystrophy; originally described by Alexander in 1949) is a rare, fatal, nonfamilial leucoencephalopathy caused by astrocyte dysfunction characterised by missense mutation in the genes coding for glial fibrillary acidic protein(GFAP). It typically presents with frontal preponderance of white matter abnormalities and macroencephaly. We report a case of leucoencephalopathy with macroencephaly that shows characteristic MRI features of Alexander disease

Topics: Macroencephaly, Leucoencephalopathy, Frontal preponderance, Periventricular rim, Cystic cavitation, Medical physics. Medical radiology. Nuclear medicine, R895-920
Publisher: AOSIS
Year: 2012
DOI identifier: 10.4102/sajr.v16i3.296
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.