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Production of fatty acid-derived valuable chemicals in synthetic microbes

By Ai-Qun eYu, Ai-Qun eYu, Nina Kurniasih Pratomo Juwono, Nina Kurniasih Pratomo Juwono, Susanna Su Jan Leong, Susanna Su Jan Leong, Susanna Su Jan Leong and Matthew Wook Chang and Matthew Wook Chang


Fatty acid derivatives, such as hydroxy fatty acids, fatty alcohols, fatty acid methyl/ethyl esters and fatty alka(e)nes, have a wide range of industrial applications including plastics, lubricants and fuels. Currently, these chemicals are obtained mainly through chemical synthesis, which is complex and costly, and their availability from natural biological sources is extremely limited. Metabolic engineering of microorganisms has provided a platform for effective production of these valuable biochemicals. Notably, synthetic biology-based metabolic engineering strategies have been extensively applied to refactor microorganisms for improved biochemical production. Here, we reviewed (i) the current status of metabolic engineering of microbes that produce fatty acid-derived valuable chemicals, and (ii) the recent progress of synthetic biology approaches that assist metabolic engineering, such as mRNA secondary structure engineering, sensor-regulator system, regulatable expression system, ultrasensitive input/output control system, and computer science-based design of complex gene circuits. Furthermore, key challenges and strategies were discussed. Finally, we concluded that synthetic biology provides useful metabolic engineering strategies for economically viable production of fatty acid-derived valuable chemicals in engineered microbes

Topics: Escherichia coli, Metabolic Engineering, Synthetic Biology, yeast, fatty acid biosynthesis pathway, biochemical production, Biotechnology, TP248.13-248.65
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fbioe.2014.00078
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