Skip to main content
Article thumbnail
Location of Repository

Discovering Che-1/AATF: a new attractive target for cancer therapy

By Simona eIezzi and Maurizio eFanciulli


The transcriptional cofactor Che-1/AATF is currently emerging as an important component of the DNA damage response machinery, the complex signaling network that maintains genome integrity and prevents tumorigenesis. Moreover this protein is involved in a wide range of cellular pathways, regulating proliferation and survival in both physiological and pathological conditions. Notably, some evidence indicates that dysregulation of Che-1/AATF levels are associated with the transformation process and elevated levels of Che-1/AATF are required for tumor cell survival. It is for these reasons that Che-1/AATF has been regarded as an attractive, still theoretical, therapeutic target for cancer treatments. In this review, we will provide an updated overview of Che-1/AATF activities, from transcriptional regulation to DNA damage response

Topics: Apoptosis, Survival, transcription, cell cycle regulation, DNA damage response, Che-1/AATF, Genetics, QH426-470
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fgene.2015.00141
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.