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Transposable elements in cancer as a by-product of stress-induced evolvability

By Tobias eMourier, Lars Peter Nielsen, Anders Johannes Hansen and Eske eWillerslev

Abstract

Transposable elements (TEs) are ubiquitous in eukaryotic genomes. Barbara McClintock's famous notion of TEs acting as controlling elements modifying the genetic response of an organism upon exposure to stressful environments has since been solidly supported in a series of model organisms. This requires the TE activity response to possess an element of specificity and be targeted towards certain parts of the genome. We propose that a similar TE response is present in human cells, and that this stress response may drive the onset of human cancers. As such, TE-driven cancers may be viewed as an evolutionary by-product of organisms' abilities to genetically adapt to environmental stress

Topics: Cancer, evolution, stress response, transposable elements, Evolvability, Genetics, QH426-470
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fgene.2014.00156
OAI identifier: oai:doaj.org/article:cb6e667ff2dc441e941f549b8890d0e7
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