Location of Repository

Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190

By Hui eZheng, Ping-Yee eLaw and Horace H Loh


Non-coding RNAs, especially micro-RNAs (miRNAs) have been reported to be involved in a variety of biological processes, including several related to the addictive drugs. The biological functions of opioids, one typical type of addictive drugs, have also been suggested to be regulated by non-coding RNAs including miRNAs. In the current review, we will examine a variety of mechanisms in which miRNAs could regulate μ-opioid receptor (OPRM1) activities. By using miR-190 as an example, we will demonstrate the critical roles played by miRNAs at the signal cascade from receptor to the systematic responses, including the possible modulations on the adult neurogenesis and in vivo contextual memory. By using miR-23b as an example, we will also examine the direct effects and mechanisms of miRNAs-mediated regulations of opioid receptor levels and how receptor signaling affects the miRNAs’ expression. Finally we will attempt to provide an discussion on the relationship and interaction between various non-coding RNAs and opioids’ functions

Topics: microRNA, non-coding RNA, miR-190, opioid addiction, Genetics, QH426-470
Publisher: Frontiers Media S.A.
Year: 2012
DOI identifier: 10.3389/fgene.2012.00113
OAI identifier: oai:doaj.org/article:869fd3968ab94f17aa3499c75a8e4eef
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1664-8021 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/869fd... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.