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miRNA-mediated deregulation in leukemia

By Carmela eDell'Aversana, Carmela eDell'Aversana and Lucia eAltucci and Lucia eAltucci

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs 18 to 22 nucleotides (nt) long able to fine-tune post-transcriptional gene expression. Extensive investigation intobiogenesis, mechanism of action and functions of miRNAs has clearly revealed their prompt control in developmental timing, differentiation, proliferation, cell death and metabolism. Deregulationof miRNA-mediated pathways may contribute to pathological conditions such as tumors, including hematological cancer, thus suggesting that miRNAs act both as tumor-suppressor genes (TSG) and oncogenes (OG).Here, we provide an overview of the current understanding of the aberration of miRNA biogenesis, activity and post-transcriptional control in leukemogenesis

Topics: Hematopoiesis, Leukemia, Cancer, epigenetics, microRNA, Genetics, QH426-470
Publisher: Frontiers Media S.A.
Year: 2012
DOI identifier: 10.3389/fgene.2012.00252
OAI identifier: oai:doaj.org/article:4dba6508e7574f8f848cdb8e8680399c
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