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Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases

By Kozo eTomita and Seisueke eYamashita

Abstract

The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3'-terminus of tRNA at one time, using CTP and ATP as substrates. The mystery of CCA-addition without a nucleic acid template by unique RNA polymerases has long fascinated researchers in the field of RNA enzymology. In this review, the mechanisms of RNA polymerization by the remarkable CCA-adding enzyme and its related enzymes are presented, based on their structural features

Topics: tRNA, CCA, template-independent, nucleotidyltransferase, class-I and II, Genetics, QH426-470
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fgene.2014.00036
OAI identifier: oai:doaj.org/article:24924c21dfa148bcbd66cdbae018dc46
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