Skip to main content
Article thumbnail
Location of Repository

Pathologic and protective roles for microglial subsets and bone marrow- and blood-derived myeloid cells in central nervous system inflammation.

By Agnieszka eWlodarczyk, Oriane eCédile, Kirstine Nolling Jensen, Agathe eJasson, Agathe eJasson, Jyothi eThyagabhavan Mony, Reza eKhorooshi and Trevor eOwens

Abstract

Inflammation is a series of processes designed for eventual clearance of pathogens and repair of damaged tissue. In the context of autoimmune recognition inflammatory processes are usually considered to be pathological. This is also true for inflammatory responses in the central nervous system (CNS). However, as in other tissues, neuroinflammation can have beneficial as well as pathological outcomes. The complex role of encephalitogenic T cells in multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE) may derive from heterogeneity of the myeloid cells with which these T cells interact within the CNS. Myeloid cells, including resident microglia and infiltrating bone marrow-derived cells such as dendritic cells (DC) and monocytes/macrophages (BMDM), are highly heterogeneous populations that may be involved in neurotoxicity but also immunoregulation and regenerative processes. Better understanding and characterization of myeloid cell heterogeneity is essential for future development of treatments controlling inflammation and inducing neuroprotection and neuroregeneration in diseased CNS. Here we describe and compare three populations of myeloid cells: CD11c+ microglia, CD11c- microglia and CD11c+ blood-derived cells in terms of their pathological versus protective functions in the CNS of mice with EAE. Our data show that CNS-resident microglia include functionally distinct subsets that can be distinguished by their expression of CD11c. These subsets differ in their expression of Arg-1, YM1, iNOS, IL-10 and IGF-1. Moreover, in contrast to BMDM/DC both subsets of microglia express protective interferon-beta (IFNβ), high levels of colony-stimulating factor-1 receptor and do not express the Th1-associated transcription factor T-bet. Taken together, our data suggest that CD11c+ microglia, CD11c- microglia and infiltrating BMDM/DC represent separate and distinct populations and illustrate the heterogeneity of the CNS inflammatory environment

Topics: Microglia, Myeloid Cells, CNS, EAE, CD11c, M1/M2, Immunologic diseases. Allergy, RC581-607
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fimmu.2015.00463
OAI identifier: oai:doaj.org/article:a1ef5f8424884d6289c7a41ae353222e
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1664-3224 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/a1ef5... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.