Location of Repository

Microbiota and mucosal immunity in amphibians

By Bruno M Colombo, Thibault eScalvenzi, Sarah eBenlamara and Nicolas ePollet and Nicolas ePollet

Abstract

We know that animals live in a world dominated by bacteria. In the last twenty years we have learned that microbes are essential regulators of mucosal immunity. Bacterias, archeas and viruses influence different aspects of mucosal development and function. Yet the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. Lastly, we propose to use Xenopus tadpoles as an alternative small animal model to improve the fundamental knowledge on immunological functions of gut microbiota

Topics: Xenopus, microbiome, mucosal immunity, chytrids, Small-animal model, Immunologic diseases. Allergy, RC581-607
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fimmu.2015.00111
OAI identifier: oai:doaj.org/article:ed13e9be00cd455babee1fbcb0eb6558
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1664-3224 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/ed13e... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.