Skip to main content
Article thumbnail
Location of Repository

Microbe-host interactions are positively and negatively regulated by galectin-glycan interactions

By Linda G. Baum, Omai B. Garner, Katrin eSchaefer and Benhur eLee and Benhur eLee

Abstract

Microbe-host interactions are complex processes that are directly and indirectly regulated by a variety of factors, including microbe presentation of specific molecular signatures on the microbial surface, as well as host cell presentation of receptors that recognize these pathogen signatures. Cell surface glycans are one important class of microbial signatures that are recognized by a variety of host cell lectins. Host cell lectins that recognize microbial glycans include members of the galectin family of lectins that recognize specific glycan ligands on viruses, bacteria, fungi and parasites. In this review, we will discuss the ways that the interactions of microbial glycans with host cell galectins positively and negatively regulate pathogen attachment, invasion and survival, as well as regulate host responses that mitigate microbial pathogenesis

Topics: Bacteria, Galectins, Viruses, Microbial Pathogenesis, cell surface glycans, Immunologic diseases. Allergy, RC581-607
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fimmu.2014.00284
OAI identifier: oai:doaj.org/article:e732d5918a994b5f98c77fbf85085125
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1664-3224 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/e732d... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.