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Intrinsic and TME-induced metabolism adaptations of T cells and impact on their differentiation and function

By soumaya ekouidhi, soumaya ekouidhi, Muhammad Zaeem eNOMAN, Claudine eKieda, amel benammar eelgaaied and Salem eChouaib


It is well recognized that the immune system and metabolism are highly integrated. In this context, multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. This review will discuss different potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. We will also provide a general framework for understanding how tumor microenvironmental metabolism, associated with hypoxic stress, interferes with T-cell priming and expansion. How T cell metabolism drives T cell–mediated immunity and how the manipulation of metabolic programming for therapeutic purposes will be also discussed

Topics: Immune System, T-Lymphocytes, Tumor Microenvironment, Cancer, hypoxia, tumor cell metabolism, Immunologic diseases. Allergy, RC581-607
Publisher: Frontiers Media S.A.
Year: 2016
DOI identifier: 10.3389/fimmu.2016.00114
OAI identifier: oai:doaj.org/article:652e437de88b4dfd9a06b2c090636a39
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