Location of Repository

Expression regulation of major histocompatibility complex (MHC) class I and class II encoding genes

By  and Peter J van den Elsen and Peter J van den Elsen

Abstract

MHC-I and MHC-II molecules play an essential role in the immune response to pathogens by virtue of their ability to present peptides to CD8+ and CD4+ T cells, respectively. Given this critical role, MHC-I and MHC-II genes are regulated in a tight fashion at the transcriptional level by a variety of transcription factors that interact with conserved cis-acting regulatory promoter elements. In addition to the activities of these regulatory factors, modification of chromatin also plays an essential role in the efficient transcription of these genes to meet with local requirement for an effective immune response. The focus of this review is on the transcription factors that interact with conserved cis-acting promoter elements and the epigenetic mechanisms that modulate induced and constitutive expression of these MHC genes

Topics: epigenetics, transcription, CIITA, MHC-I, MHC-II, Immunologic diseases. Allergy, RC581-607
Publisher: Frontiers Media S.A.
Year: 2011
DOI identifier: 10.3389/fimmu.2011.00048
OAI identifier: oai:doaj.org/article:5043276d97b84a3db225a604605748c7
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1664-3224 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/50432... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.