Location of Repository

Resting-state functional connectivity in anterior cingulate cortex in normal aging

By Weifang eCao, Cheng eLuo, Dan eZhang, Bin eZhu, Li eDong, Jinnan eGong, Diankun eGong, Hui eHe, Shipeng eTu, Wenjie eYin, Jianfu eLi and Dezhong eYao

Abstract

Growing evidence suggests that normal aging is associated with cognitive decline and well-maintained emotional well-being. The anterior cingulate cortex (ACC) is an important brain region involved in emotional and cognitive processing. We investigated resting-state functional connectivity (FC) of two ACC subregions in 30 healthy older adults versus 33 healthy younger adults, by parcellating into rostral (rACC) and dorsal (dACC) ACC based on clustering of FC profiles. Compared with younger adults, older adults demonstrated greater connection between rACC and anterior insula, suggesting that older adults recruit more proximal dACC brain regions connected with insula to maintain a salient response. Older adults also demonstrated increased FC between rACC and superior temporal gyrus and inferior frontal gyrus, decreased integration between rACC and default mode, and decreased dACC-hippocampal and dACC-thalamic connectivity. These altered FCs reflected rACC and dACC reorganization, and might be related to well emotion regulation and cognitive decline in older adults. Our findings provide further insight into potential functional substrates of emotional and cognitive alterations in the aging brain

Topics: Aging, fMRI, functional connectivity, resting state, anterior cingulate cortex., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fnagi.2014.00280
OAI identifier: oai:doaj.org/article:71581d72a86f458e993c3460a9f95c44
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1663-4365 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/71581... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.