Location of Repository

Bioenergetic dysfunction and inflammation in alzheimer's disease: a possible connection

By Heather M Wilkins, Heather M Wilkins, Steven M Carl, Alison eGreenlief, Barry eFestoff, Barry eFestoff, Barry eFestoff, Barry eFestoff and Russell H Swerdlow and Russell H Swerdlow and Russell H Swerdlow and Russell H Swerdlow


Inflammation is observed in Alzheimer’s disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no foreign agent has been implicated. This suggests that internally produced damage-associated molecular pattern molecules (DAMPs) may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed

Topics: Inflammation, Mitochondria, Alzheimer’s disease, Bioenergetics, DAMP, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fnagi.2014.00311
OAI identifier: oai:doaj.org/article:7169deae75ac48a3916fd9698be5b127
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1663-4365 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/7169d... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.