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Mechanisms of Sensorineural Cell Damage, Death and Survival in the Cochlea

By Allen Frederic Ryan, Allen Frederic Ryan, Allen Frederic Ryan and Ann Chi Yan Wong and Ann Chi Yan Wong

Abstract

The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well as the survival signaling pathways that can provide endogenous protection and tissue rescue. These data have primarily been generated in hearing loss not directly related to age. However, there is evidence that similar mechanisms operate in presbycusis. Moreover, accumulation of damage from other causes can contribute to age-related hearing loss. Potential therapeutic interventions to balance opposing but interconnected cell damage and survival pathways, such as antioxidants, anti-apoptotics, and pro-inflammatory cytokine inhibitors, are also discussed

Topics: Inflammation, Presbycusis, reactive oxygen species (ROS), Age-related hearing loss (ARHL), Sensorineural hearing loss (SNHL), hair cells (HCs), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fnagi.2015.00058
OAI identifier: oai:doaj.org/article:961c72bc997c417d9df5e9cdece38d92
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