Location of Repository

Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers

By Marta Karolina Zamroziewicz, Marta Karolina Zamroziewicz, Marta Karolina Zamroziewicz, Erick Joseph Paul, Erick Joseph Paul, Rachael Danielle Rubin, Rachael Danielle Rubin, Rachael Danielle Rubin and Aron K Barbey and Aron K Barbey and Aron K Barbey and Aron K Barbey and Aron K Barbey and Aron K Barbey and Aron K Barbey


Introduction: Although diet has a substantial influence on the aging brain, the relationship between biomarkers of diet and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between omega-3 polyunsaturated fatty acids (O3PUFAs) and executive functions in at-risk (APOE e4 carriers), cognitively intact older adults. We hypothesized that higher levels of O3PUFAs are associated with better performance in a particular component of the executive functions, namely cognitive flexibility, and that this relationship is mediated by gray matter volume of a specific region thought to be important for cognitive flexibility, the anterior cingulate cortex. Methods: We examined 40 cognitively intact adults between the ages of 65 and 75 with the APOE e4 polymorphism to investigate the relationship between biomarkers of O3PUFAs, tests of cognitive flexibility (measured by the Delis-Kaplan Executive Function System Trail Making Test), and gray matter volume within regions of the prefrontal cortex. Results: A mediation analysis revealed that gray matter volume within the left rostral anterior cingulate cortex partially mediates the relationship between O3PUFA biomarkers and cognitive flexibility. Conclusion: These results suggest that the anterior cingulate cortex acts as a mediator of the relationship between O3PUFAs and cognitive flexibility in cognitively intact adults thought to be at risk for cognitive decline. Through their link to executive functions and neuronal measures of prefrontal cortex volume, O3PUFAs show potential as a nutritional therapy to prevent dysfunction in the aging brain

Topics: Executive Function, cognitive aging, Omega-3 fatty Acids, anterior cingulate cortex (ACC), Nutritional neuroscience, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fnagi.2015.00087
OAI identifier: oai:doaj.org/article:995ead06d8354d6bb1dfe8a911d3d243
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1663-4365 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/995ea... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.