Location of Repository

Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS

By Maria Teresa eCarri, Maria Teresa eCarri, Cristiana eValle, Cristiana eValle, Francesca eBozzo, Francesca eBozzo and Mauro eCozzolino

Abstract

It is well known that mitochondrial damage is both the major contributor to oxidative stress (the condition arising from unbalance between production and removal of reactive oxygen species) and one of the major consequences of oxidative stress, because of the high dependence of mitochondrial function on redox-sensitive targets such as intact membranes.Conditions in which neuronal cells are not able to cope with mitochondrial damage and oxidative stress seem to lead or contribute to several neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS), at least in the most studied SOD1-linked genetic variant.As summarized in this review, new evidence indicates that mitochondrial damage and oxidative stress play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials

Topics: Amyotrophic Lateral Sclerosis, Mitochondria, Oxidative Stress, neurodegeneration, ALS, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fncel.2015.00041
OAI identifier: oai:doaj.org/article:e1e2a872a8f74a83bef292faf8f2b597
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1662-5102 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/e1e2a... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.