Skip to main content
Article thumbnail
Location of Repository

CD44: molecular interactions, signalling and functions in the nervous system.

By Grzegorz Marek Wilczynski and Joanna eDzwonek

Abstract

CD44 is the major surface hyaluronan receptor implicated in intercellular and cell-matrix adhesion, cell migration and signalling. It is a transmembrane, highly glycosylated protein with several isoforms resulting from alternative gene splicing. The CD44 molecule consists of several domains serving different functions: the N-terminal extracellular domain, the stem region, the transmembrane domain and the C-terminal tail. In the nervous system, CD44 expression occurs in both glial and neuronal cells. The role of CD44 in the physiology and pathology of the nervous system is not entirely understood, however, there exists evidence suggesting it might be involved in the axon guidance, cytoplasmic Ca2+ clearance, dendritic arborization, synaptic transmission, epileptogenesis, oligodendrocyte and astrocyte differentiation, post-traumatic brain repair and brain tumour development

Topics: adhesion molecule, CD44, Hyaluronic acid binding protein, hyaluronan receptor, extracellular matrix receptor, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fncel.2015.00175
OAI identifier: oai:doaj.org/article:0401d60fc37b41309854bd368b5d2085
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/1662-5102 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/0401d... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.