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The thalamus as a low pass filter: filtering at the cellular level does not equate with filtering at the network level.

By William Martin Connelly, William Martin Connelly, Michael eLaing, Adam Clarke Errington and Vincenzo eCrunelli and Vincenzo eCrunelli

Abstract

In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiological parameters, we show that the thalamus behaves akin to a low pass filter. Specifically, as individual cells in the thalamus rely on consistent drive to spike, stimuli that is rapidly and continuously changing over time such that it activates sensory cells with different receptive fields are unable to drive thalamic spiking. This means that thalamic encoding is robust to sensory noise, however it induces a lag in sensory representation. Thus the thalamus stabilises encoding of sensory information, at the cost of response rate

Topics: Thalamus, Sensory Neuroscience, computational neuroscience, integrate-and-fire neuron, neural noise, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2016
DOI identifier: 10.3389/fncir.2015.00089
OAI identifier: oai:doaj.org/article:0fa11fd667e94ec888bc3b378e028726
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