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Bimanual non-congruent actions in motor neglect: a combined behavioral/fMRI study

By Francesca eGarbarini, Luca eTurella, Luca eTurella, Marco eRabuffetti, Anna eCantagallo, Alessandro ePiedimonte, Enrico eFainardi, Anna Maria Berti and Luciano eFadiga and Luciano eFadiga

Abstract

In Motor Neglect (MN) syndrome, a specific impairment in non-congruent bimanual movements has been described. In the present case-control study, we investigated the neuro-functional correlates of this behavioral deficit. Two right-brain-damaged patients, one with (MN+) and one without (MN-) MN, were evaluated by means of functional Magnetic Resonance Imaging (fMRI) in a bimanual Circles-Lines paradigm. Patients were requested to perform right-hand movements (lines-drawing) and, simultaneously, congruent (lines-drawing) or non-congruent (circles-drawing) left-hand movements. In the behavioral task, MN- patient showed a bimanual-coupling-effect, while MN+ patient did not. The fMRI study showed that in MN-, a fronto-parietal network, mainly involving the pre-supplementary motor area (pre-SMA) and the posterior parietal cortex (PPC), was significantly more active in non-congruent than in congruent conditions, as previously shown in healthy subjects. On the contrary, MN+ patient showed an opposite pattern of activation both in pre-SMA and in PPC. Within this fronto-parietal network, the pre-SMA is supposed to exert an inhibitory influence on the default coupling of homologous muscles, thus allowing the execution of non-congruent movements. In MN syndrome, the described abnormal pre-SMA activity supports the hypothesis that a failure to inhibit ipsilesional motor programs might determine a specific impairment of non-congruent movements

Topics: fMRI, motor neglect, bimanual actions, Bimanual coupling effect, supplementary and pre-supplementary motor area (pre-SMA; SMA)
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fnhum.2015.00541
OAI identifier: oai:doaj.org/article:220c856f9ab74385bbbcada9fd079a14
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