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Tau: The Center of a Signaling Nexus in Alzheimer’s Disease

By Shahzad eKhan and George S. Bloom

Abstract

Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer’s disease (AD). This review discusses the role of tau in amyloid-β (Aβ) induced toxicity in AD. The consequences of tau dysfunction, starting from the axon and concluding at somadendritic compartments, will be highlighted

Topics: synaptic dysfunction, Tau phosphorylation, Alzheimer’s disease (AD), Amyloid-β oligomers (AβOs), Neurofibrillary tangles (NFTs), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2016
DOI identifier: 10.3389/fnins.2016.00031
OAI identifier: oai:doaj.org/article:2d27ebcae0c942feadf0567f01abdace
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