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Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurones.

By Celine eBidoret, Celine eBidoret, Guy eBouvier, Annick eAyon, German eSzapiro and Mariano eCasado


N-methyl-D-aspartate receptors (NMDARs) in cerebellar molecular layer interneurones (MLIs) are expressed and activated in unusual ways: at parallel fibre synapses they are only recruited by repetitive stimuli, suggesting an extrasynaptic location, whereas their activation by climbing fibre is purely mediated by spillover. NMDARs are thought to play an important role in plasticity at different levels of the cerebellar circuitry. Evaluation of the location, functional properties and physiological roles of NMDARs will be facilitated by knowledge of the NMDAR isoforms recruited. Here we show that MLI-NMDARs activated by both parallel fibre and climbing fibre inputs have similar kinetics and contain GluN2B but not GluN2A subunits. On the other hand, no evidence was found of functional NMDARs in the axons of MLIs. At the parallel fibre - Purkinje cell (PF-PC) synapse, the activation of GluN2A-containing NMDARs has been shown to be necessary for the induction of long-term depression. Our results therefore provide a clear distinction between the NMDARs located on MLIs and those involved in plasticity at PF-PC synapses

Topics: cerebellum1, NMDA receptors2, interneuron3, plasticity4, parallel fibers5, climbing fibers6., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fnsyn.2015.00001
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