Skip to main content
Article thumbnail
Location of Repository

Effects of epithelial to mesenchymal transition on T cell targeting of melanoma cells.

By Katherine eWoods, Katherine eWoods, Anupama ePasam, Anupama ePasam, Aparna eJayachandran, Aparna eJayachandran, Miles eAndrews, Miles eAndrews and Jonathan eCebon and Jonathan eCebon

Abstract

Melanoma cells can switch phenotype in a manner similar to epithelial to mesenchymal transition(EMT). In this perspective article, we address the effects of such phenotype switching on T cell targeting of tumour cells. During the EMT-like switch in phenotype, a concomitant change in expression of multiple tumour antigens occurs. Melanoma cells undergoing EMT escape from killing by T cells specific for antigens whose expression is downregulated by this process. We discuss melanoma antigens whose expression is influenced by EMT. We assess the effect of changes in the expressed tumour antigen repertoire on T cell mediated tumour recognition and killing.In addition to escape from T cell immunity via changes in antigen expression, mesenchymal-like melanoma cells are generally more resistant to classical chemotherapy and radiotherapy. However, we demonstrate that when targeting antigens whose expression is unaltered during EMT, the capacity of T cells to kill melanoma cell lines in vitro is not influenced by their phenotype. When considering immune therapies such as cancer vaccination, these data suggest escape from T cell killing due to phenotype switching in melanoma could potentially be avoided by careful selection of target antige

Topics: Melanoma, T-Lymphocytes, Tumor antigens, Epithelial-mesenchymal transition (EMT), T-cell killing, Cancer testis antigens, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Publisher: Frontiers Media S.A.
Year: 2014
DOI identifier: 10.3389/fonc.2014.00367
OAI identifier: oai:doaj.org/article:5afb7983265a4eb7bf85c142b147787f
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2234-943X (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/5afb7... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.