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Organization and dynamics of SNARE proteins in the presynaptic membrane

By Dragomir eMilovanovic and Reinhard eJahn


Our view of the lateral organization of lipids and proteins in the plasma membrane has evolved substantially in the last few decades. It is widely accepted that many, if not all, plasma membrane proteins and lipids are organized in specific domains. These domains vary widely in size, composition, and stability, and they represent platforms governing diverse cell functions. The presynaptic plasma membrane is a well-studied example of a membrane which undergoes rearrangements, especially during exo- and endocytosis. Many proteins and lipids involved in presynaptic function are known, and major efforts have been made to understand their spatial organization and dynamics. Here, we focus on the mechanisms underlying the organization of SNAREs, the key proteins of the fusion machinery, in distinct domains, and we discuss the functional significance of these clusters

Topics: SNARE Proteins, clustering, membrane domains, hydrophobic interaction, Ionic interaction, modularity of cluster formation, Physiology, QP1-981
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fphys.2015.00089
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