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Attention deficit hyperactivity disorder in the light of the epigenetic paradigm

By Viviane eSchuch, Daniel Augusto Utsumi, Mauro eMuszkat, Thais Virgínia Moura Machado Costa and Leslie Domenici Kulikowski


Attention deficit hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder characterized by a definite behavioral pattern that might lead to performance problems in the social, educational or work environments. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), the symptoms of ADHD were restricted to those associated with cognitive (attention deficit) and behavioral (hyperactivity/impulsivity) deficits, while deficient emotional self-regulation (DESR), a relevant source of morbidity, was left out. The etiology of it is complex, as its exact causes have not yet been fully elucidated. ADHD seems to arise from a combination of various genetic and environmental factors that alter the developing brain, resulting in structural and functional abnormalities. The aim of this paper was to review epigenetics and ADHD focused on how multidimensional mechanisms influence the behavioral phenotype

Topics: epigenetics, executive functions, environmental factors, ADHD, genetic factors, emotional self-regulation, Psychiatry, RC435-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fpsyt.2015.00126
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