Skip to main content
Article thumbnail
Location of Repository

The impact of neuroimmune alterations in autism spectrum disorder

By Carmem eGottfried, Victorio eBambini, Fiona eFrancis, Rudimar eRiesgo and Wilson eSavino


Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. In the past decade, studies of ASD have substantially increased, in both humans and animal models. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of proinflammatory cytokines observed in postmortem brain from patients, as well as autoantibody production. Also, epidemiological studies have established a correlation of ASD with family history of autoimmune diseases; associations with major histocompatibility complex haplotypes and abnormal levels of immunological markers in the blood. Moreover, the use of animal models to study ASD is providing increasing information on the relationship between the immune system and the pathophysiology of ASD. Herein, we will discuss the accumulating literature for ASD, giving special attention to the relevant aspects of factors that may be related to the neuroimmune interface in the development of ASD, including changes in neuroplasticity

Topics: Valproic Acid, autism, rodent models, neuroimmune interactions, Environmental risk factors, Psychiatry, RC435-571
Publisher: Frontiers Media S.A.
Year: 2015
DOI identifier: 10.3389/fpsyt.2015.00121
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.