Background and aims: Comorbidity social anxiety and depression is one of the most common problems adolescents that of destructive consequences for them. Therefore, the aim of this study was to investigate the effectiveness of mindfulness–based cognitive therapy on interpretation bias and dysfunctional attitude in patients with suffering disorder comorbidity social anxiety and depression.\ud Methods: The design of the current study was semi-experimental, pre-test, post-test and follow-up design with control group. Statistical population of this study consisted of all female students of the first and second class in high school, suffering comorbidity social anxiety and depression in Khorramabad city. With the purpose of fulfilling the study, screening was conducted; and at first, 437 participants with the age range of 14-17, completed the social anxiety and depression questionnaires. Among the participants, the 30 patients with suffering social anxiety and high depression (one standard deviation above group average) were selected. Then, the selected 30 individuals were randomly divided into two experimentation and control groups, each containing 15 individuals. Experimentation group was imposed to training the MBCT during 8 sessions; each session lasted for 2 hours. After completing the sessions, both the groups responded to interpretation and dysfunctional attitude questionnaires.\ud Results: Experimental group evidenced statistically significant reductions after training in self interpretation bias, others (P<0.001) and dysfunctional attitudes (P<0.05). Findings were also preserved in the follow-up phase.\ud Conclusion: According to the results, mindfulness-based training to reduce interpretation biases and dysfunctional attitudes in patients with suffering disorder comorbidity social anxiety and depression is recommended.\u
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