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Insights on bovine genetic engineering and cloning

By Fabiana F. Bressan, Juliano R. Sangalli, Laís V.F. Pessôa, Pedro R.L. Pires and Flávio V. Meirelles

Abstract

Transgenic technology has become an essential tool for the development of animal biotechnologies, and animal cloning through somatic cell nuclear transfer (SCNT) enabled the generation of genetically modified animals utilizing previously modified and selected cell lineages as nuclei donors, assuring therefore the generation of homogeneous herds expressing the desired modification. The present study aimed to discuss the use of SCNT as an important methodology for the production of transgenic herds, and also some recent insights on genetic modification of nuclei donors and possible effects of gene induction of pluripotency on SCNT

Topics: Induced pluripotency, transgenic technology, somatic cell nuclear transfer, cattle, Veterinary medicine, SF600-1100
Publisher: Colégio Brasileiro de Patologia Animal (CBPA)
DOI identifier: 10.1590/S0100-736X2013001300018
OAI identifier: oai:doaj.org/article:fcf8f3b5d777484ea0fecc6f389c5bac
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