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Hepatitis C virus antibodies in high risk juvenile onset systemic lupus erythematosus

By Nádia E. Aikawa, Ana P. Nascimento, André L.S. Hayata, Eloisa Bonfá and Cláudia Goldenstein-Schainberg


Abstract Objective To evaluate the prevalence of hepatitis C virus (HCV) infection in high risk juvenile systemic lupus erythematosus (JSLE). Study design Forty low income JSLE patients (6M:34F; mean age 19 ± 4.4 yrs; mean disease duration 6 ± 3.2 yrs) were studied. Twenty healthy children and adolescents matched for social economical level were included as controls. Anti-HCV tests were performed using a third generation microparticle enzyme immunoassay. Inclusion criterion was low social economical level. Results The frequencies of anti-HCV antibody were low and comparable between JSLE and control group (2.5% vs. 0, p = 1.0). JSLE patients had significantly more risk factors for HCV infection compared to the control group, including immunosuppressive treatment (90% vs. 0, p < 0.0001), hospitalization (50% vs. 12.5%, p = 0.0006) and invasive procedures (47.5% vs. 12.5%, p = 0.001). Conclusions The observed low frequency of anti-HCV antibodies in high risk JSLE suggests that this virus does not seem to have a relevant role in the pathogenesis of this disease

Topics: Vírus contra a hepatite C, Anti-VHC, Lúpus eritematoso sistêmico de início juvenil, Diseases of the musculoskeletal system, RC925-935
Publisher: Sociedade Brasileira de Reumatologia
Year: 2016
DOI identifier: 10.1016/j.rbre.2016.02.011
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