Skip to main content
Article thumbnail
Location of Repository

Polymorphism rs3828903 within MICB Is Associated with Susceptibility to Systemic Lupus Erythematosus in a Northern Han Chinese Population

By Yue-miao Zhang, Xu-jie Zhou, Fa-juan Cheng, Yuan-yuan Qi, Ping Hou, Ming-hui Zhao and Hong Zhang

Abstract

Objectives. The variant rs3828903 within MICB, a nonclassical MHC class I chain-related gene, was detected to contribute to systemic lupus erythematosus (SLE) in a Caucasian population. This study aimed to investigate the association in a northern Han Chinese population. Methods. We recruited 1077 SLE patients and 793 controls for analysis. rs3828903 was genotyped by TaqMan allele discrimination assay. Using the public databases, its functional annotations and gene differential expression analysis of MICB were evaluated. Results. Significant association between the allele G of rs3828903 and risk susceptibility to SLE was observed after adjusting for sex and age (P=1.87×10-2). In silico analyses predicted a higher affinity to transcription factors for allele G (risk) and cis-expression quantitative trait loci (cis-eQTL) effects of rs3828903 in multiple tissues (P ranging from 2.79×10-6 to 6.27×10-38). Furthermore, higher mRNA expressions of MICB were observed in B cells, monocytes, and renal biopsies from SLE patients compared to controls. Conclusion. An association between rs3828903 and susceptibility to SLE has been detected in a Chinese population. This together with the functional annotations of rs3828903 converts MICB into a main candidate in the pathogenesis of SLE

Topics: Immunologic diseases. Allergy, RC581-607
Publisher: Hindawi Publishing Corporation
Year: 2016
DOI identifier: 10.1155/2016
OAI identifier: oai:doaj.org/article:a85554cf95494b768cfa0b616ac7c288
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2314-7156 (external link)
  • https://doaj.org/toc/2314-8861 (external link)
  • http://dx.doi.org/10.1155/2016... (external link)
  • https://doaj.org/article/a8555... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.