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Low CD4+ T cell counts are not risk factor for Malassezia species infection in HIV/AIDS patients

By Agnes Sri Siswati Satiti Retno Pudjiati Epi Panjaitan

Abstract

Human immunodefiiency virus (HIV) infection and aquired immunodeficiency syndrome (AIDS) cause a progressive depletion of CD4+ T cell populations accompanied by progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections. Seborrheic dermatitis is one of the most common skin opportunistic infections on HIV/AIDS patients. Malassezia species is bilieved as the causative of seborrheic dermatitis. The aim of the study was to evaluate low CD4+ T cell counts as risk factor for Malassezia sp. infection in HIV/AIDS patients. This was an observational study with cross-sectional design conducted on HIV/AIDS patients who attended in Department of Dermatology and Venereology, Faculty of Medicine Universitas Gadjah Mada/ Dr Sardjito General Hospital, Yogyakarta and met the inclusion and exclusion criteria. Culture of Malassezia sp. was conducted in Department of Microbiology and classified as high (>100 CFU/ tape) and low (<100 CFU/tape) density colonies. CD4+ T cell counts were measured in Department of Clinical Pathology and classified as high (>200 cells/mm3) and low (<200 cells/mm3) CD4+ T cell counts. A total of 83 subjects with HIV/AIDS comprising 54 (65.1%) males and 29 (34.9%) females aged 20 - >60 years were involved in the study. The number of Malassezia sp. colony on subjects with high and low CD4+ T cell counts were 31.55 ± 26.21 and 25.2 ± 33.89 CFU/ tape, respectively. No significantly relationship between between CD4+ T cell count and Malassezia sp. colony number was observed in the study (p=0.607; 95%CI=0.04-5.19; RP=0.452). In conclusion, low CD4+ T cell counts is not risk factor for Malassezia sp. infection in HIV/AIDS patients

Topics: Medicine, R, Medicine (General), R5-920
Publisher: Universitas Gadjah Mada
Year: 2015
OAI identifier: oai:doaj.org/article:68b651b62539464089143eb5edee7681
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