Location of Repository

The influence of early neutrophil-Leishmania interactions on the host immune response to infection

By Flavia eRibeiro-Gomes and David eSacks

Abstract

Neutrophils are the first cells recruited to the dermal site of Leishmania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite and apoptotic fate, and the nature of their encounters with other innate cells. We suggest that the influence of the neutrophil response on infection outcome critically depends on the timing of their recruitment and the tissue environment in which it occurs

Topics: Apoptosis, Dendritic Cells, Inflammation, Leishmania, Macrophages, Neutrophils, Microbiology, QR1-502
Publisher: Frontiers Media S.A.
Year: 2012
DOI identifier: 10.3389/fcimb.2012.00059
OAI identifier: oai:doaj.org/article:fb3f467c46564676b1485e40c4a6a2a9
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2235-2988 (external link)
  • http://journal.frontiersin.org... (external link)
  • https://doaj.org/article/fb3f4... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.