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Francisella recognition by inflammasomes: differences between Mice and Men

By Mikhail A Gavrilin and Mark D Wewers


Pathogen recognition by intracellular sensors involves the assembly of a caspase-1 activation machine termed the inflammasome. Intracellular pathogens like Francisella that gain access to the cytosolic detection systems are useful tools to uncover the details of caspase-1 activation events. This review overviews Francisella function in the mononuclear phagocyte with particular attention to inflammasome versus pyroptosome roles and outlines differences between mouse and human caspase-1 activation pathways. Specific attention is placed on functional differences between human and murine pyrin as an intracellular recognition molecule for Francisella

Topics: Francisella, Monocytes, Inflammasome, AIM2, IL-1beta, pyrin, Microbiology, QR1-502
Publisher: Frontiers Media S.A.
Year: 2011
DOI identifier: 10.3389/fmicb.2011.00011
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