Skip to main content
Article thumbnail
Location of Repository

Development of vaccines against Burkholderia pseudomallei

By Natasha ePatel, Laura eConejero, Anna eEaston, Melanie eDeReynal, Gregory J Bancroft and Richard W Titball


Burkholderia pseudomallei is a Gram-negative bacterium which is the causative agent of melioidosis, a disease which carries a high mortality and morbidity rate in endemic areas of South East Asia and Northern Australia. At present there is no available human vaccine that protects against B. pseudomallei, and with the current limitations of antibiotic treatment, the development of new preventative and therapeutic interventions is crucial. This review considers the multiple elements of melioidosis vaccine research including: i) the immune responses required for protective immunity, ii) animal models available for preclinical testing of potential candidates, iii) the different experimental vaccine strategies which are being pursued, and iv) the obstacles and opportunities for eventual registration of a licensed vaccine in humans

Topics: Burkholderia, Melioidosis, Vaccines, pseudomallei, Microbiology, QR1-502
Publisher: Frontiers Media S.A.
Year: 2011
DOI identifier: 10.3389/fmicb.2011.00198
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.